All-trans Retinoic Acid induced Myositis in a Patient with Acute Promyelocytic Leukemia.
- Author:
Yoon Seok KOH
;
Seok LEE
;
Yoo Jin KIM
;
Jusang KIM
;
Seok In HONG
;
Yoon Hee PARK
;
Hee Je KIM
;
Dong Wook KIM
;
Jong Wook LEE
;
Woo Sung MIN
;
Chun Choo KIM
- Publication Type:Case Report
- Keywords:
All-trans retinoic acid;
Myositis;
Acute promyelocytic leukemia
- MeSH:
Antineoplastic Agents;
Humans;
Leukemia;
Leukemia, Promyelocytic, Acute*;
Myositis*;
Receptors, Retinoic Acid;
Sweet Syndrome;
Tretinoin*
- From:Korean Journal of Hematology
2003;38(3):191-194
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acute promyelocytic leukemia (APL) is characterized by a specific chromosome translocation t(15;17), which fuses the promyelocytic leukemia (PML) gene to the retinoic acid receptor alpha (RARalpha) gene, and by a unique response to the differentiating agent all-trans retinoic acid (ATRA). Although ATRA does not exhibit the conventional side effects of anticancer agents, it has its own unique side effects including retinoic acid syndrome, Sweet's syndrome, and myositis. Muscular involvement associated with ATRA therapy in APL has been rarely reported. We report a case of isolated myositis induced by ATRA in the induction treatment of APL. ATRA- induced myositis has distinctive clinical features and radiologic findings that should allow its recognition in order to treat promptly with steroid therapy.
