A Case of Coexistent Chronic Lymphocytic Leukemia and Multiple Myeloma.
- Author:
Seung Hyun NAM
1
;
Jung Mi KWON
;
Yeung Chul MUN
;
Kyung Eun LEE
;
Sook Younk LEE
;
Wha Soon CHUNG
;
Soon Nam LEE
;
Chu Myong SEONG
Author Information
- Publication Type:Case Report
- Keywords: Coexistence; Chronic lymphocytic leukemia; Multiple myeloma
- MeSH: Aged; Bone Marrow; Diagnosis; Doxorubicin; Drug Therapy; Electrophoresis; Humans; Immunoelectrophoresis; Immunoglobulin G; Incidence; Leukemia, Lymphocytic, Chronic, B-Cell*; Lymphocytes; Multiple Myeloma*; Paraproteinemias; Plasma Cells; Pneumonia; Sepsis
- From:Korean Journal of Hematology 2005;40(1):41-44
- CountryRepublic of Korea
- Language:Korean
- Abstract: Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are both lymphoproliferative disease occurring in different stages of B cell oncogeny. An increased incidence of secondary malignancies in patients with CLL is well recognized, however, the coexistence of both disorders in the same patient was very rare. Furthermore, clonal relationship between these diseases has not been clearly established. We report the occurrence of MM during the course of CLL. A 68-year-old patient was presented with general weakness and bone marrow aspiration showed a hypercellular marrow with 80% mature lymphocytes. At 5 months after diagnosis of CLL, bone marrow of the patient showed increased immature plasma cells. Serum protein electrophoresis showed monoclonal gammopathy and serum immunoelectrophoresis IgG kappa type monoclonality. The patient received six cycles of VAD (vincristine, adriamycin, dexamethasone) chemotherapy, but died of pneumonia and sepsis.
