A Case of Serum Amino Acid Disturbance with Hyperammonemia in Patient with Primary Amyloidosis.
- Author:
Yuri KIM
1
;
Jin Seok KIM
;
Sun Young PARK
;
In Hae PARK
;
June Won CHEONG
;
Seung Tae LEE
;
Yoo Hong MIN
;
Jee Sook HAHN
;
Jeong Hae KIE
Author Information
- Publication Type:Case Report
- Keywords: Amyloidosis; Amino acid disturbance; Hyperammonemia
- MeSH: Amino Acids; Amino Acids, Aromatic; Amino Acids, Branched-Chain; Ammonia; Amyloidosis*; Consciousness; Female; Humans; Hyperammonemia*; Korea; Liver; Multiple Myeloma; Unconsciousness
- From:Korean Journal of Hematology 2005;40(1):54-57
- CountryRepublic of Korea
- Language:Korean
- Abstract: There have been reports that hyperammonemia and amino acid disturbance can cause loss of consciousness in patients with multiple myelomas and normal liver function. We experienced a case of a 71-years-old female patient with amyloidosis, who had shown disturbance of consciousness. At that time, the serum ammonia level was elevated; serum amino acids disturbance was also noted. In particular, the decrease in branched-chain amino acids and increase in aromatic amino acids results in a low Fisher ratio. The Fisher ratio, the ratio of branched-chain to aromatic amino acids, has been suggested as an important indicator of consciousness disturbance. We report, for the first time in Korea, a case of amyloidosis, with mental disturbance due to serum amino acid disturbance.
