Two Cases of Acquired Hemophilia A Successfully Treated with Oral Steroid or Danazol.
- Author:
Sun Young PARK
1
;
Jin Seok KIM
;
Yuri KIM
;
In Hae PARK
;
June Won CHEONG
;
Seung Tae LEE
;
Jee Sook HAHN
;
Yoo Hong MIN
Author Information
- Publication Type:Case Report
- Keywords: Acquired hemophilia A; Factor VIII inhibitor; Immunosuppressive therapy
- MeSH: Adult; Aged; Aged, 80 and over; Autoantibodies; Autoimmune Diseases; Consensus; Danazol*; Diagnosis; Factor VIII; Hemophilia A*; Hemorrhage; Humans; Immunosuppression; Mortality; Postpartum Period
- From:Korean Journal of Hematology 2005;40(1):58-63
- CountryRepublic of Korea
- Language:Korean
- Abstract: Acquired Hemophilia A is a rare and considerably life-threatening coagulopathy, which is caused by the development of autoantibodies against factor VIII (FVIII) in non-hemophilic adults. Acquired FVIII inhibitors can be associated with diverse conditions, such as malignant disorders, medications, autoimmune diseases, postpartum states and others. These autoantibodies inhibit normal coagulation, had results in bleeding complications, which can contribute to mortality in a high percentages of cases. Effective control of the disorder can be achieved by prompt diagnosis and appropriate managements. Generally, the managements of acquired hemophilia A are aimed at treating the acute bleeding and eliminating inhibitors by immunosuppression. Although a range of treatment options exists for patients with acquired hemophilia A, there is no consensus with regard to the optimal therapies for this disorder. Herein, two cases, an 82-year-old man and a 78-year-old man who were successfully treated by steroid or danazol, which is a relatively mild immunosuppressive agent, are reported.
