A Case of Combined POEMS Syndrome and Multiple Myeloma with Positive M protein Only on Immunofixation.
10.5045/kjh.2008.43.4.253
- Author:
Jae Hoon YANG
1
;
Joo Young JUNG
;
Chan Soo SO
;
Yu Jin LIM
;
Seung Yong HAN
;
Sarah PARK
;
Jung Han KIM
;
Mina HUR
;
Gyung Kyu LEE
;
Jung Weon SHIM
;
Young Iee PARK
Author Information
1. Division of Internal Medicine, Hangang Sacred Heart Hospital, Seoul, Korea. jyj822@hanmail.net
- Publication Type:Case Report
- Keywords:
POEMS syndrome;
Multiple myeloma;
Osteoblastic lesion
- MeSH:
Biopsy;
Edema;
Electrophoresis;
Giant Lymph Node Hyperplasia;
Humans;
Lower Extremity;
Middle Aged;
Multiple Myeloma;
Osteoblasts;
Papilledema;
Paraproteinemias;
Paresthesia;
Peripheral Nervous System Diseases;
Plasma Cells;
Plasmacytoma;
POEMS Syndrome;
Polyneuropathies;
Skin;
Specialization
- From:Korean Journal of Hematology
2008;43(4):253-257
- CountryRepublic of Korea
- Language:English
-
Abstract:
POEMS syndrome is a plasma cell proliferative disorder is characterized by the presence of peripheral neuropathy (P), organomegaly (O), monoclonal gammopathy (M), endocrinopathy or edema (E) and skin change (S). It can be rarely related to multiple myeloma. A 48-year-old man was admitted to our hospital due to paresthesia of both inguinal areas and weakness of both lower extremities. He had a history of Castleman's disease, and showed features of polyneuropathy, multiple osteoblastic lesions, hepatosplenomegaly, pretibial pitting edema, and papilledema. The serum and urine electrophoresis were negative, but urine immunofixagion could detect monoclonal protein. Plasmacytoma was confirmed through the biopsy for the osteoblastic lesions. We present a case of combined POEMS syndrome and multiple myeloma with positive M protein only on immunofixation in order to share our experience with physicians and specialists.
