Acute Tubulointerstitial Nephritis Induced by Deferasirox following Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia.
10.5045/kjh.2008.43.4.258
- Author:
Jae Woong MIN
1
;
Seung Jae HWANG
;
Yeon Jung LIM
;
Young Ho LEE
Author Information
1. Department of Pediatrics, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Korea. cord@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Exjade;
Deferasirox;
Nephritis;
Acute renal failure;
Aplastic anemia;
Transfusion;
Iron;
Transplantation;
Hematopoietic cell
- MeSH:
Acute Kidney Injury;
Anemia, Aplastic;
Benzoates;
Creatinine;
Deferoxamine;
Exanthema;
Hematopoietic Stem Cell Transplantation;
Hematopoietic Stem Cells;
Hemosiderosis;
Humans;
Iron;
Iron Overload;
Liver;
Nephritis;
Nephritis, Interstitial;
Triazoles
- From:Korean Journal of Hematology
2008;43(4):258-262
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Deferasirox is a once-daily, oral iron-chelating agent that is now widely available for the treatment of transfusional hemosiderosis. Deferasirox represents a significant advance in the treatment of iron overload, as the availability of an effective oral therapy has the potential to relieve many patients from the burden of frequent parenteral therapy with the previous reference standard iron chelator, deferoxamine. The well-known drug-related adverse events associated with deferasirox include gastrointestinal disturbances, rash, elevations in liver enzyme levels, and mild increases in serum creatinine levels, but acute renal failure is not common. The authors report a case of acute tubulointerstitial nephritis induced by deferasirox following hematopoietic stem cell transplantation for severe aplastic anemia
