A Case of Natural Killer-Large Granular Lymphocyte (NK-LGL) Leukemia.
- Author:
Jung Ho LEE
1
;
Soo Jin PARK
;
Sang Eun PARK
;
Seung Keun KWAK
;
Hyun Young SHIN
;
Sung Eun KIM
;
Jung Chan LEE
;
Hwan Jung YUN
;
Deog Yeon JO
;
Samyong KIM
;
So Young SHIN
;
Kye Chul KWON
;
Jong Woo PARK
Author Information
1. Department of Internal Medicine, College of Medicine, Chungnam National University, Taejeon, Korea.
- Publication Type:Case Report
- Keywords:
Large granular lymphocyte (LGL);
NK-LGL leukemia
- MeSH:
Hematologic Neoplasms;
HLA-DR Antigens;
Humans;
Immunophenotyping;
Leukemia*;
Leukemia, Large Granular Lymphocytic;
Leukocytes;
Lymphocytes*;
Middle Aged
- From:Korean Journal of Hematology
2001;36(3):269-273
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Large granular lymphocyte (LGL) leukemia, a rare hematologic malignancy, is classified into two groups, CD3+ T-LGL leukemia and CD3- NK-LGL leukemia based upon immunophenotype of the cells. We describe a patient with NK-LGL leukemia, who showed a rapidly fatal course. A 56-year-old man was presented with a very high count of white blood cells (154,400/mm3) consisting of mostly LGLs. Immunophenotyping using flow cytometric analysis revealed that majority of the cells were positive for HLA-DR and CD56 but negative for all the myeloid and lymphoid markers. Despite of active supportive care, he died of coagulopathy and multi-organ failure on the sixth hospital day.
