The Clinical Significance of Ann Arbor and Musshoff's Staging System in Primary Gastrointestinal Non-Hodgkin's Lymphoma-A Retrospective Analysis.
- Author:
Kwang Woon SEO
1
;
Dong Hwan KIM
;
Woo Jin SUNG
;
Sung Won PARK
;
Jong Gwang KIM
;
Jin Tae JUNG
;
Tae In PARK
;
Se Hwan KIM
;
Dong Gun SHIN
;
Sang Kyun SOHN
;
Kyu Bo LEE
Author Information
1. Department of Internal Medicine, Kyungpook National University, School of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Primary Gastrointestinal Lymphoma;
Musshoff's modified staging system;
Ann Arbor staging system
- MeSH:
Classification;
Disease-Free Survival;
Hodgkin Disease;
Prognosis;
Retrospective Studies*;
Survival Rate
- From:Korean Journal of Hematology
2001;36(4):275-285
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Primary Gastrointestinal Non- Hodgkin's Lymphoma (GIL) represents 4 to 20 % of all Non-Hodgkin's Lymphoma(NHL) and gastrointestinal tract(GIT) is the most frequently involved extranodal site in NHL. It is known that the prognosis of GIL is better than that of other NHLs because of it's unique biologic behavior and anatomical location. We reviewed clinical aspects of GIL and analyzed survival data based on Ann-Arbor and Musshoff's staging system. METHODS: Sixty six cases were analyzed by age, sex, clinical manifestation, location, histology, clinical course, and two staging systems (Ann Arbor and Musshoff's modified staging). Histologies were reviewed according to REAL classification. RESULTS: The median age was 51.5 years. The most frequent gross finding was ulcerofungating lesion in upper GIL and mass lesion in lower GIL. Treatment results were as following : 76.9% of response rate, 59.5% of 5-year overall survival rate, and 54.8% of 5-year disease free survival rate. There was a significant difference of overall survival or disease free survival rate between group below stage IIE1 and above IIE2 according to Musshoff's staging system. There were no significant differences in survival between stage I and II, and between stage III and IV based on Ann Arbor staging system. CONCLUSION: There might be the necessity of discriminating localized disease (IIE1) and locally advanced lesion (IIE2) to predict the prognosis of GIL through Musshoff's staging system. Larger study will be needed to confirm the role of Musshoff's staging system.
