A Case of Chronic Neutrophilic Leukemia Associated with Increased Respiratory Burst Activity of Neutrophils.
- Author:
Na RanHi LEE
1
;
Seock Ah IM
;
Kyung Eun LEE
;
Do Yeun KIM
;
Eun Mi NAM
;
Seong Eun KIM
;
So Hyeon LEE
;
Ji Eun CHANG
;
Jee Eun CHANG
;
Moon Sun YEOUM
;
Hae Jung YEOUM
;
Jung Mi KWON
;
Young Ju CHOI
;
Chu Myoung SEONG
;
Soon Nam LEE
;
Ju Young SEO
;
Hee Jin HUH
;
Wha Soon CHUNG
Author Information
1. Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea. moisa@ewha.ac.kr
- Publication Type:Case Report
- Keywords:
Chronic neutrophilic leukemia;
Neutrophil;
Increased respiratory burst
- MeSH:
Aged;
Alkaline Phosphatase;
Humans;
Karyotype;
Leukemia, Neutrophilic, Chronic*;
Leukemoid Reaction;
Leukocyte Count;
Leukocytes;
Luminescence;
Myeloproliferative Disorders;
Myristic Acid;
Neutrophils*;
Philadelphia Chromosome;
Respiratory Burst*;
Uric Acid;
Vitamin B 12
- From:Korean Journal of Hematology
2001;36(4):359-363
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Chronic neutrophilic leukemia is a rare myeloproliferative disorder. We have experienced a typical case of chronic neutrophilic leukemia in a 76-year-old man who complained abdominal distension due to hepatosplenomegaly. White blood cell count of peripheral blood was 50,500/nL with 90% segmented neutrophils. The underlying disease for a leukemoid reaction had not been detected. Leukocyte alkaline phosphatase score and the serum levels of vitamin B12 and uric acid were elevated. Chromosome study showed a normal karyotype without Philadelphia chromosome or bcr/abl rearrangement. Phorbol myristate acetate-activated respiratory burst activity of neutrophils measured with chemiluminescence showed increased activity.
