Rhabdomyosarcoma Presenting as Acute Leukemia Identified by Cytogenetic and FISH Analysis of Bone Marrow.
- Author:
Jin Yeong HAN
1
;
Kyeong Hee KIM
;
Jae Seok KIM
;
Hyo Jin KIM
;
Yong Sung LEE
;
Lisa G SHAFFER
Author Information
1. Department of Clinical Pathology, Dong-A University College of Medicine, Pusan, Krorea.
- Publication Type:Original Article
- Keywords:
Rhabdomyosarcoma;
Leukemic presentation;
Tumor cytogenetics;
t(2;
13) (q35;
q14);
FISH
- MeSH:
Adolescent;
Adult;
Anemia;
Bone Marrow*;
Child;
Cytogenetic Analysis;
Cytogenetics*;
Diagnosis;
Female;
Fluorescence;
Humans;
Immunophenotyping;
In Situ Hybridization;
Leukemia*;
Metaphase;
Paint;
Rhabdomyosarcoma*;
Rhabdomyosarcoma, Alveolar;
Thrombocytopenia
- From:Korean Journal of Hematology
2000;35(3-4):297-301
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Rhabdomyosarcoma is the most common malignant soft tissue tumor in children. In adults, however, it is extremely rare, with only a few cases observed. We describe a case of an adolescent who presented with hematologic findings compatible with acute leukemia. A 35-year-old woman was transferred to the Dong-A University Hospital for further evaluation of thrombocytopenia, anemia, and ovarian mass lesions. The peripheral blood film showed a leukoerythroblastic picture with circulating blasts. The bone marrow was markedly hypercellular and 85.6 % of all nucleated cells were atypical tumor cells. Immunophenotyping with both myeloid and lymphoid markers was all negative. With cytogenetic analysis of bone marrow 8 of 11 metaphases were characterized by a translocation t(2;13)(q35;q14), strongly indicated a diagnosis of alveolar rhabdomyosarcoma. Fluorescence in situ hybridization (FISH) using whole chromosome paints for chromosomes 2 and 13 confirmed the cytogenetic diagnosis.
