Multiple Chromosomal Abnormalities Accompanying Disseminated Granulocytic Sarcoma in Recurrent Acute Myelogenous Leukemia 50,XY,+8,+10,del(15)(q13),+21,+22.
- Author:
Hyun Il KIM
1
;
Yeon Hee PARK
;
Han Jin KWON
;
Soo Youb CHAE
;
Seung Hye ANN
;
Hyo Jin LEE
Author Information
1. Department of Internmal Medicine, Seoul Adventist Hospital, Seoul, Korea. oncology@unitel.co.kr
- Publication Type:Case Report
- Keywords:
Recurrent AML;
Granulocytic sar- coma;
Chromosomal abnormality
- MeSH:
Chromosome Aberrations*;
Drug Therapy;
Humans;
Leukemia, Myeloid, Acute*;
Lymphoma;
Prognosis;
Sarcoma, Myeloid*
- From:Korean Journal of Hematology
2001;36(1):100-104
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It is known that acute myelogenous leukemia (AML) carries chromosomal abnormalities in 55-78% of patients, and that chromosomal abnormalities were associated with pathophysiology of disease, clinical feature, and it's prognosis. Granulocytic sarcoma occurring in 2~14% of AML is especially associated with t(8;21), is common to misdiagnose as malignant lymphoma, and has poor prognosis as survival of 5.4 months due to poor response to chemotherapy. Hereby we report a case of recurrent AML occurred as granulocytic sarcoma carring multiple chromosomal aberration without accompanying t(8;21).
