A case of transfusion-related acute lung injury induced by anti-human leukocyte antigen antibodies in acute leukemia.
10.5045/kjh.2012.47.4.302
- Author:
Sun Mi JIN
1
;
Moon Ju JANG
;
Ji Young HUH
;
Myoung Hee PARK
;
Eun Young SONG
;
Doyeun OH
Author Information
1. Department of Internal Medicine, CHA University School of Medicine, Seongnam, Korea. doh@cha.ac.kr
- Publication Type:Case Report
- Keywords:
Transfusion-related acute lung injury (TRALI);
Transfusion;
Anti-human leukocyte antigen (anti-HLA) antibody
- MeSH:
Acute Lung Injury;
Antibodies;
Blood Group Incompatibility;
Blood Platelets;
Critical Illness;
Hematologic Neoplasms;
Humans;
Leukemia;
Leukocytes;
Pulmonary Edema;
Risk Factors;
Sepsis
- From:Korean Journal of Hematology
2012;47(4):302-306
- CountryRepublic of Korea
- Language:English
-
Abstract:
Transfusion-related acute lung injury (TRALI) is a noncardiogenic pulmonary edema that occurs during or within 6 hours after transfusion. Risk factors for TRALI, which is relatively common in critically ill patients, include recent surgery, hematologic malignancy, and sepsis. Here, we report a case of TRALI induced by anti-human leukocyte antigen (anti-HLA) class II antibodies (HLA-DR) occurring after transfusion of platelet concentrates in a patient with acute leukemia. Although most patients with TRALI show improvement within 48-96 hours, our patient's condition rapidly worsened, and he did not respond to supportive treatment. TRALI is a relatively common and serious adverse transfusion reaction that requires prompt diagnosis and management.
