Clinical significance of anti-mitochondrial antibodies in a patient with chronic graft-versus-host disease following hematopoietic stem cell transplantation.
10.5045/kjh.2011.46.3.200
- Author:
Dong Hyun LEE
1
;
Seok Jae HUH
;
Hyun Hwa YOON
;
Sung Woo LEE
;
Kyeong Hee KIM
;
Sung Hyun KIM
Author Information
1. Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. kshmoon@dau.ac.kr
- Publication Type:Case Report
- Keywords:
Autoantibody;
Anti-mitochondrial antibody;
Chronic graft-versus-host disease;
Hematopoietic stem cell transplantation
- MeSH:
Antibodies;
Diagnosis, Differential;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation;
Hematopoietic Stem Cells;
Humans;
Liver Cirrhosis, Biliary
- From:Korean Journal of Hematology
2011;46(3):200-202
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recent studies indicate that patients with chronic graft-versus-host disease (GVHD) are not expected to show positivity for anti-mitochondrial antibody (AMA), which is a specific disease marker for primary biliary cirrhosis (PBC). A differential diagnosis between PBC and hepatic involvement of GVHD based on clinical manifestations and pathologic study is difficult because both diseases show similar results. Therefore, the presence of AMA may be important for distinguishing each disease. Here, we report a case of hepatic involvement of chronic GVHD with positive AMA, in which the pathologic findings and initial presentation of clinical findings were compatible with both PBC and chronic GVHD.
