A Case of Acute Undifferentiated Leukemia with Trisomy 13.
- Author:
Eun Jin KIM
1
;
Dong Seok JEON
;
Jae Ryong KIM
;
Gui Jeon CHOI
;
Jung Suk HA
;
Ki Young KWON
Author Information
1. Department of Clinical Pathology, College of Medicine, Keimyung University, Taegu, Korea.
- Publication Type:Case Report
- Keywords:
Acute undifferentiated leukemia;
Trisomy 13;
CD34;
HLA-DR
- MeSH:
Anemia;
Bone Marrow;
Bone Marrow Cells;
Chromosome Aberrations;
Cytogenetics;
Diagnosis;
HLA-DR Antigens;
Humans;
Immunophenotyping;
Induction Chemotherapy;
Leukemia*;
Leukocytosis;
Male;
Peroxidase;
Prognosis;
Trisomy*
- From:Korean Journal of Hematology
1999;34(1):148-152
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The diagnosis of acute undifferentiated leukemia is made when the leukemic cells cannot be classified using morphologic and cytochemical analyses, and do not express myeloid or lymphoid antigens. Trisomy 13 is a rare primary chromosomal abnormality in acute leukemia and associated with lineage inconsistency and poor prognosis. We report a rare case of acute undifferentiated leukemia showing negativity in periodic acid-Schiff (PAS) and myeloperoxidase (MPO) without any lineage-specific cell surface marker expression and having trisomy 13. The patient was a 72- year-old male who visited our hospital because of anemia and general weakness. On examination, leukocytosis with proliferated blasts (76%) in peripheral blood was noted. Bone marrow aspirate showed blast proliferation (74%) with morphologically hand-mirror type. The blast expressed CD34 (96%) and HLA-DR (76%) in immunophenotyping. Cytogenetic study of bone marrow cells showed 46,XY,+13,-21[15]/46,XY[5]. Induction chemotherapy was failed and differentiation to monocytic series was noted.
