A Case of Cerebral Syndrome Associated with High-Dose Cytosine Arabinoside Chemotherapy.
- Author:
Yoon Soo CHANG
1
;
So Young CHONG
;
Yoo Hong MIN
;
Jee Sook HAHN
;
Yun Woong KO
Author Information
1. Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
High-Dose Ara-C Chemotherapy;
Neurotoxicity;
Cerebral Syndrome
- MeSH:
Bone Marrow;
Cytarabine*;
Cytosine*;
Drug Therapy*;
Gastrointestinal Tract;
Humans;
Leukemia;
Lymphoma;
Male;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Recurrence;
Young Adult
- From:Korean Journal of Hematology
1999;34(1):157-162
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cytosine arabinoside (Ara-C) is a highly active agent in the treatment of acute leukemia and malignant lymphoma. The use of high-dose Ara-C therapy has been advanced as a possible means of overcoming resistance. High dose Ara-C regimens are occasionally associated with cerebellar and cerebral toxicities while toxicities in conventional dose regimens are mainly restricted to the bone marrow and gastrointestinal tract. A 21-year-old male patient with acute lymphoblastic leukemia in second relapse developed cerebral syndrome 10 days after high-dose Ara-C chemotherapy. We present a case of acute cerebral toxicity after high dose Ara-C chemotherapy with relevant literature review.
