CD56+ T-cell Prolymphocytic Leukemia Showing a High Expression Level of TCL1 Oncogene: A Case Report with a Review of the Literature.
10.5045/kjh.2006.41.2.129
- Author:
Hyeong Kee YUN
1
;
Myung Geun SHIN
;
Hyeoung Joon KIM
;
Hye Ran KIM
;
Ji Young PARK
;
Duck CHO
;
Seung Jung KEE
;
Young Hyu KIM
;
Jong Hee SHIN
;
Soon Pal SUH
;
Dong Wook RYANG
Author Information
1. Department of Laboratory Medicine, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Korea. mgshin@chonnam.ac.kr
- Publication Type:Case Report
- Keywords:
T-cell Prolymphocytic Leukemia;
TCL1;
CD56
- MeSH:
Bone Marrow;
Immunophenotyping;
Leukemia, Prolymphocytic, T-Cell*;
Liver;
Lymph Nodes;
Oncogenes*;
Polymerase Chain Reaction;
Prognosis;
Skin;
Spleen;
T-Lymphocytes*
- From:Korean Journal of Hematology
2006;41(2):129-133
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
T-cell prolymphocytic leukemia (T-PLL) is a rare mature post-thymic T-cell malignancy with infiltration to the blood, bone marrow, lymph node, liver, spleen and skin; this disease has a poor prognosis and an aggressive clinical course. We report here on a case of CD56+ T-PLL that was diagnosed by hematological examination, immunophenotyping and molecular studies including determining the TCL1 expression by using reverse-transcriptase polymerase chain reaction (RT-PCR), and direct sequencing of the RT-PCR product.
