Chronic graft versus host disease with small bowel obstruction after unrelated hematopoietic stem cell transplantation in a patient with acute myeloid leukemia.
10.5045/kjh.2012.47.2.142
- Author:
Ju Young YOON
1
;
Hyery KIM
;
Hyoung Jin KANG
;
Kyung Duk PARK
;
Hee Young SHIN
;
Hyo Seop AHN
Author Information
1. Department of Pediatrics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. hyshin@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Acute myeloid leukemia;
Hematopoietic stem cell transplantation;
Graft versus host disease;
Intestinal obstruction
- MeSH:
Child;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation;
Hematopoietic Stem Cells;
Humans;
Ileum;
Intestinal Obstruction;
Intestine, Small;
Leukemia, Myeloid, Acute;
Tissue Donors;
Transplants
- From:Korean Journal of Hematology
2012;47(2):142-145
- CountryRepublic of Korea
- Language:English
-
Abstract:
Chronic graft versus host disease (GVHD) is a frequent complication after allogeneic hematopoietic stem cell transplantation (HSCT), but simultaneous small bowel obstruction is rare. Here, we report a child with acute myeloid leukemia who received an allogeneic HSCT from an unrelated matched donor. After HSCT, the patient developed severe chronic GVHD involving the small intestine, leading to obstruction of the terminal ileum. Small bowel resection was performed, and the symptoms improved without severe complications. Bowel obstruction should be considered as a possible complication of chronic GVHD; surgery may be a valuable corrective measure.
