A Case of Idiopathic CD4+ T-lymphocytopenia Associated with Autoimmune Hemolytic Anemia.
- Author:
Seong Gyu LEE
1
;
Sung Hwan BYUN
;
Jong Woon CHOI
;
Hyun Soo KIM
Author Information
- Publication Type:Case Report
- Keywords: Idiopathic CD4+ T-lymphocytopenia; Otitis media; Pulmonary infection; Autoimmune hemolytic anemia
- MeSH: Anemia, Hemolytic, Autoimmune*; Centers for Disease Control and Prevention (U.S.); Child, Preschool; Down Syndrome; HIV; HIV Infections; Humans; Lymphoma, Non-Hodgkin; Male; Opportunistic Infections; Otitis Media; Risk Factors; Sarcoidosis, Pulmonary; Sjogren's Syndrome; T-Lymphocytes; T-Lymphocytopenia, Idiopathic CD4-Positive*
- From:Korean Journal of Hematology 2007;42(1):53-57
- CountryRepublic of Korea
- Language:Korean
- Abstract: Idiopathic CD4+ T-lymphocytopenia (ICL) is defined by the CDC as depressed numbers of circulating CD4+ T-lymphocytes (<300 cells/microliter or <20% of the total T cells) on more than one determination, with the absence of HIV infection and other known causes of immunodeficiency. The clinical spectrum of ICL ranges from asymptomatic laboratory abnormalities to severe opportunistic infections that mimic the clinical course of human immunodeficiency virus (HIV) infected patients. There are a few reports of ICL associated with different diseases such as Sjogren's syndrome, pulmonary sarcoidosis, Down syndrome or non-Hodgkin's lymphoma. We describe here a 5-year-old male patient with a three-year history of recurrent otitis media and pulmonary infection, and he was without any risk factors for HIV infection; this patient presented with autoimmune hemolytic anemia and was ultimately found to have idiopathic CD4+ T-lymphocytopenia.
