A Case of Heparin Induced Thrombocytopenia with Circulating Anti-PF4/Heparin Antibody.
- Author:
Yangsoon LEE
1
;
Juwon KIM
;
Jaewoo SONG
;
Kyoung Soon SONG
Author Information
- Publication Type:Case Report
- Keywords: Heparin induced thrombocytopenia; Anti-PF4/heaprin antibody; ELISA (Asserachrom HPIA, Diagnostia Stago, Asnieres, France)
- MeSH: Angiography; Antibodies; Coronary Artery Bypass; Coronary Artery Disease; Dyspnea; Enzyme-Linked Immunosorbent Assay; Heparin*; Immunoglobulin A; Platelet Activation; Platelet Count; Thrombocytopenia*; Thromboplastin; Transplants
- From:Korean Journal of Hematology 2007;42(1):67-70
- CountryRepublic of Korea
- Language:Korean
- Abstract: Heparin-induced thrombocytopenia (HIT) is usually caused by anti-platelet factor 4 (PF4)/heparin antibodies, leading to intravascular platelet activation. Circulating anti-PF4/heaprin antibody (IgG, IgA and IgM) was detected by ELISA (Asserachrom HPIA, Diagnostia Stago, Asnieres, France) in a 61-yearold man with coronary artery disease and dyspnea on exercise. He had undergone a coronoary angiography using 2,000 unit of heparin before a procedure. On admission, laboratory testing revealed a platelet count of 296x10(9)/L and aPTT (activated partial thromboplastin time) of 38.1 sec. The fall in the platelet count was progressive, resulting in 42% and 53% of platelet counts on the 6th and 12th days after intravenous heparin administration, respectively. He was discharged after coronary artery bypass graft. On discharge, platelet count was normalized to be 212x10(9)/L. On the 7th day after dischage, anti-PF4/heaprin antibody was detected by ELISA (Asserachrom HPIA, Diagnostia Stago, Asnieres, France).
