The Clinical Guidelines for Myelodysplastic Syndrome.
- Author:
June Won CHEONG
1
;
Hoon KOOK
;
Soo Mee BANG
;
Je Hwan LEE
;
Yong Don JOO
;
Inho KIM
;
Hyeoung Joon KIM
;
Chan Jeoung PARK
;
Hyeon Jin PARK
;
Jin Seok AHN
;
Sung Soo YOON
;
Jong Ho WON
;
Mark Hong LEE
;
Chul Won JUNG
;
Deog Yeon JO
;
Bin CHO
;
Kyoung Ja HAN
;
Yoo Hong MIN
;
Sun Hee KIM
Author Information
- Publication Type:Review
- Keywords: Myelodysplastic syndrome; Guideline; Diagnosis; Hypomethylating agents; Transplantation; Response criteria; Iron chelating treatment; MDS in childhood
- MeSH: Aged; Diagnosis; Hematopoiesis; Humans; Iron Overload; Mortality; Myelodysplastic Syndromes*; Transplantation
- From:Korean Journal of Hematology 2007;42(2):71-90
- CountryRepublic of Korea
- Language:Korean
- Abstract: The myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis associated with multilineage cytopenias leading to serious morbidity or mortality, and the additional risk of leukemic transformation. The management of patients with MDS can be very complex and varies according to both the clinical manifestations in individual patients as well as the presence of complicating medical conditions. However, therapeutic dilemmas still exist for MDS due to the multifactorial pathogenetic features of the disease, its heterogeneous stages, and the elderly patient population. For these reasons, proper guidelines for management are necessary. This review describes the proper diagnosis for MDS, decision-making approaches for optimal therapeutic options that are based on a consideration of patient clinical factors and risk-based prognostic categories, and the use of recently available biospecific drugs such as hypomethylating agents that are potentially capable of abrogating the abnormalities associated with MDS. Proper indications and methods for transplantation, response criteria, management for iron overload for highly transfused patients and specific considerations for MDS in childhood are also described. All of these topics were discussed at the third symposium of AML/MDS working party on 3 March, 2007.
