Expression of Granulocyte Colony-Stimulating Factor Receptor (G-CSFR) and Clinical Correlates in Acute Leukemia.
- Author:
Soo Young YOON
1
;
Sook Young BAE
;
Jae Hong SEO
;
Byung Soo KIM
;
Young Kee KIM
;
Kap No LEE
;
Insoo RHEEM
Author Information
1. Department of Laboratory Medicine, Korea University School of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Granulocyte colony-stimulating factor (G-CSF) receptor;
Acute leukemia;
Flow cytometry
- MeSH:
Bone Marrow;
Drug Therapy;
Flow Cytometry;
Granulocyte Colony-Stimulating Factor*;
Granulocytes*;
Humans;
Leukemia*;
Leukemia, Biphenotypic, Acute;
Leukemia, Myeloid, Acute;
Leukocytes;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Recurrence
- From:Korean Journal of Hematology
2003;38(4):246-252
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Granulocyte colony-stimulating factor (G-CSF) is commonly used to reduce leukopenic period during treatment of malignancy including acute leukemia. Leukemic blasts expressing granulocyte colony-stimulating factor receptor (G-CSFR) were reported and also may proliferate in response to therapeutic administration of G-CSF. However, it is not clear whether G-CSFR expression on leukemic blasts is related to clinical outcome such as leukocyte recovery or leukemia relapse. Current study evaluated expression of G-CSFR in acute leukemia and correlated with hematologic and clinical parameters. METHODS: Peripheral blood or bone marrow aspirate was evaluated from 20 patients with acute myelogenous leukemia (AML) and 10 with acute lymphoblastic leukemia (ALL), 2 with acute undifferentiated leukemia (AUL), 1 with acute biphenotypic leukemia (ABL), 1 with acute mixed-lineage leukemia (AMLL). G-CSFR expression was analyzed using flow cytometry and was correlated with immunophenotype and response for chemotherapy. RESULTS: More than 20% of blasts were positive for G-CSFR in 65% (13/20) of AML, 40% (4/10) of ALL, and all negative in ABL, AMLL, and AUL. Except that all 6 monocytic lineage leukemias (M4, M5) and all three cases of ALL with CD33 expression were positive, no consistent correlation was observed among G-CSFR expression pattern, type of acute leukemia, response to induction therapy and relapse (P>0.05). CONCLUSION: Current study revealed G-CSFR was expressed on not only myelogenous leukemic cells but also lymphoid ones. Although our data suggest G-CSFR expression does not affect therapeutic outcome, it remains to be determined whether G-CSF therapy is safe in G-CSFR-positive acute leukemia.
