A Case of Successful Allogeneic Stem Cell Transplantation for Chemotherapy-refractory Hepatosplenic gamma delta-T Cell Lymphoma.
10.5045/kjh.2009.44.4.284
- Author:
Sung Bin KIM
1
;
Su Hyeon JEONG
;
Jin Hee PARK
;
Hye Soo KIM
;
Bu Kyung KIM
;
Ho Sup LEE
Author Information
1. Department of Internal Medicine, College of Medicine, Kosin University Gospel Hospital, Busan, Korea. hs3667@hanmail.net
- Publication Type:Case Report
- Keywords:
Hepatosplenic;
gamma delta T-cell;
Stem cell transplantation
- MeSH:
Adult;
Antibodies, Monoclonal, Humanized;
Bone Marrow;
Boronic Acids;
Cisplatin;
Female;
Humans;
Liver;
Lymphoma;
Lymphoma, T-Cell;
Lymphoma, T-Cell, Peripheral;
Organoplatinum Compounds;
Prednisone;
Pyrazines;
Siblings;
Spleen;
Stem Cell Transplantation;
Stem Cells;
Tissue Donors;
Transplants;
Vincristine;
Bortezomib
- From:Korean Journal of Hematology
2009;44(4):284-288
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hepatosplenic T-cell lymphoma is a rare histologic type of peripheral T-cell lymphoma, which is characterized clinically by predominant involvement of the liver and spleen, with little or no adenopathy, and an often aggressive course. We experienced a case of a 44-year-old female who was diagnosed with hepatosplenic gamma delta T-cell lymphoma with bone marrow involvement. The patient was treated with multi- agent chemotherapy with Bortezomib plus CHOP (cyclophosphamide, vincristine, prednisone, doxorubicin), Alemtuzumab plus DHAP (dexamethasone, cisplatin, cytarabine), and IMVP-16 (Ifosfamide, MTX, etoposide); however, she failed to achieve partial remission. After salvage chemotherapy (GemOx: Gembicine, oxaliplatin, dexamethasone), she underwent allogeneic stem cell transplantation from an HLA sibling donor with one mismatch . The patient is currently living and has remained in complete remission for 6 months since transplantation.
