Successful Hematopoietic Stem Cell Transplantation in Myelodysplastic Syndrome with Invasive Fungal Infection: A Case Report.
10.5045/kjh.2009.44.4.289
- Author:
Hyun Su KIM
1
;
Se Hyung KIM
;
Hyun Jung KIM
;
Sang Cheol LEE
;
Sang Byung BAE
;
Chan Kyu KIM
;
Kyu Teak LEE
;
Seong Kyu PARK
;
Jong Ho WON
;
Dae Sik HONG
;
Hee Sook PARK
;
Eun Ju CHOO
Author Information
1. Department of Hematology-Oncology, Soonchunhyang University School of Medicine, Bucheon, Korea. skpark@schbc.ac.kr
- Publication Type:Case Report
- Keywords:
Myelodysplastic syndrome;
Hematopoietic stem cell transplantation;
Aspergillosis
- MeSH:
Aspergillosis;
Bone Marrow;
Cause of Death;
Hematopoiesis;
Hematopoietic Stem Cell Transplantation;
Hematopoietic Stem Cells;
Humans;
Myelodysplastic Syndromes;
Transplants
- From:Korean Journal of Hematology
2009;44(4):289-293
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Myelodysplastic syndrome (MDS) is a heterogeneous group of disorders characterized by ineffective hematopoiesis, morphological dysplasia, peripheral blood cytopenias, and progressive bone marrow failure. The only proven curative treatment for MDS is hematopoietic stem cell transplantation. However, invasive fungal infection following hematopoietic stem cell transplantation has become the leading cause of death from infection. Therefore, transplant candidates with previous invasive fungal infection have often been excluded from the transplant program due to high risk of reactivation and associated death. We report on a case involving an MDS patient with complications from invasive aspergillosis who had shown no response to amphotericin-B. The patient underwent successfully unrelated allogeneic hematopoietic stem cell transplantation.
