Mutation of the N-ras Gene in a Patient Suffering from the Blast Phase of Chronic Myelogenous Leukemia.
10.5045/kjh.2009.44.2.100
- Author:
Sung Heon SONG
1
;
Young Wook ROH
;
Yong Woo AHN
;
Yeon Jae KIM
;
Young Sang BYOUN
;
Ji Young CHOI
;
Deok Won HWANG
;
Byoung Bae PARK
;
Jung Hye CHOI
;
In Soon KIM
;
Byoung Kook KIM
;
Young Yiul LEE
Author Information
1. Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea. leeyy@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Chronic myelogenous leukemia;
Gene mutation;
Blast phase;
N-ras
- MeSH:
Blast Crisis;
Genes, p53;
Genes, ras;
Humans;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
Point Mutation;
Stress, Psychological
- From:Korean Journal of Hematology
2009;44(2):100-103
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The blast phase in chronic myelogenous leukemia (CML) is associated with mutation of several genes. It is well known that p53 gene mutation plays a key role in the myeloid or lymphoid blast phase of CML. But for the case of the N-ras gene, the association between N-ras mutations and the blast phase of CML is not yet known. We report here on a case of detecting N-ras point mutation without p53 mutation in a 64 year-old man who suffered from the lymphoblastic blast phase of CML.
