Cross-Sectional Relations of Arterial Stiffness and Inflammatory Markers in Korean Adults Aged 50 Years and Older.
- Author:
So Yeon RYU
1
;
Min Ho SHIN
;
Young Hoon LEE
;
Jung Ae RHEE
;
Jin Su CHOI
;
Kyeong Soo PARK
;
Hae Sung NAM
;
Seul Ki JEONG
;
Sun Seog KWEON
Author Information
1. Department of Preventive Medicine, Chosun University Medical School, Korea.
- Publication Type:Original Article
- Keywords:
Arterial stiffness;
Inflammation;
Pulse wave velocity
- MeSH:
Adult;
Aged;
Alanine Transaminase;
Blood Pressure;
Body Mass Index;
C-Reactive Protein;
Cardiovascular Diseases;
Cholesterol;
Fasting;
gamma-Glutamyltransferase;
Glucose;
Humans;
Hypertension;
Inflammation;
Leukocytes;
Pulse Wave Analysis;
Risk Factors;
Smoke;
Smoking;
Surveys and Questionnaires;
Triglycerides;
Uric Acid;
Vascular Stiffness
- From:Journal of Agricultural Medicine & Community Health
2011;36(2):101-112
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The aim of this study is to determine arterial stiffness levels as measured by brachial-ankle pulse wave velocity (baPWV) and to identify the association between arterial stiffness and inflammatory markers, in healthy adults over 50 years old. METHODS: The study population consisted of 4617 persons over the age of 50 years who participated in the baseline survey of the Dong-gu Study, which was conducted in 2007 and 2008. Arterial stiffness was measured using baPWV. A multiple regression analysis was performed to assess the relationship between conventional cardiovascular risk factors and inflammatory markers, including white blood cell (WBC) counts, high-sensitive C-reactive protein (hs-CRP), and gamma glutamyltransferase (GGT). RESULTS: After adjustment for conventional cardiovascular risk factors including sex, age, smoking status, body mass index, systolic blood pressure, fasting glucose, hypertension or diabetic medication, total cholesterol, triglycerides, uric acid, and alanine aminotransferase, baPWV was significantly associated with WBC counts (beta=0.158, p<0.0001), hs-CRP (beta=0.244, p=0.026), and GGT (beta=0.003, p<0.0001). CONCLUSION: This study shows that arterial stiffness correlates with inflammatory markers. Arterial stiffness may be used as a composite risk factor to identify persons with higher risk for cardiovascular disease. Additionally, arterial stiffness may be a marker for future cardiovascular disease and a target for prevention.
