Research progress on acute lung injury and lung protective strategies by cardiopulmonary bypass
10.7507/1007-4848.201805007
- VernacularTitle:体外循环急性肺损伤与肺保护策略的研究进展
- Author:
SHEN Jiayu
1
;
ZHANG Eryong
1
;
HU Jia
1
Author Information
1. Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass;
systemic inflammatory response syndrome;
ischemia-reperfusion injury;
acute lung injury;
lung protection
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2019;26(2):186-191
- CountryChina
- Language:Chinese
-
Abstract:
Acute lung injury is a kind of common complication after cardiopulmonary bypass. Acute lung injury is attributed to the ischemia-reperfusion injury and systemic inflammatory response syndrome. Several factors common in cardiac surgery with cardiopulmonary bypass may worsen the risk for acute lung injury including atelectasis, transfusion requirement, older age, heart failure, emergency surgery and prolonged duration of bypass. Targets for prevention of acute lung injury include mechanical, surgical and anesthetic interventions that aim to reduce the contact activation, systemic inflammatory response, leukocyte sequestration and hemodilution associated with cardiopulmonary bypass. We aim to review the etiology, risk factors and lung protective strategies for acute lung injury after cardiopulmonary bypass.
