S-1 Based Doublet as an Adjuvant Chemotherapy for Curatively Resected Stage III Gastric Cancer: Results from the Randomized Phase III POST Trial.
- Author:
Choong kun LEE
1
;
Minkyu JUNG
;
Hyo Song KIM
;
Inkyung JUNG
;
Dong Bok SHIN
;
Seok Yun KANG
;
Dae Young ZANG
;
Ki Hyang KIM
;
Moon Hee LEE
;
Bong Seog KIM
;
Kyung Hee LEE
;
Jae Ho CHEONG
;
Woo Jin HYUNG
;
Sung Hoon NOH
;
Hyun Cheol CHUNG
;
Sun Young RHA
Author Information
- Publication Type:Multicenter Study ; Original Article
- Keywords: Stomach neoplasms; Stage III; S-1 based doublet; Docetaxel; Cisplatin; Adjuvant chemotherapy
- MeSH: Anemia; Capecitabine; Chemotherapy, Adjuvant*; Cisplatin; Disease-Free Survival; Follow-Up Studies; Gastrectomy; Hand-Foot Syndrome; Humans; Korea; Lymph Node Excision; Mucositis; Neutropenia; Stomach Neoplasms*
- From:Cancer Research and Treatment 2019;51(1):1-11
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: We conducted a randomized, multicenter, phase III trial to compare S-1 plus docetaxel (DS) with S-1 plus cisplatin (SP) as adjuvant chemotherapy for stage III gastric cancer patients. MATERIALS AND METHODS: Stage III gastric cancer patients who had received curative gastrectomy with D2 lymphadenectomy were randomized into equal groups to receive adjuvant chemotherapy of eight cycles of DS (S-1 70 mg/m2/day on days 1-14 plus docetaxel 35 mg/m2on days 1 and 8) every 3 weeks or SP (S-1 70 mg/m2/day on days 1-14 plus cisplatin 60 mg/m2on day 1) every 3 weeks. The primary endpoint was 3-year disease-free survival (DFS) rate. RESULTS: Between November 2010 and July 2013, 153 patients (75 patients to DS and 78 patients to SP) were enrolled from 8 institutions in Korea. After the capecitabine plus oxaliplatin was approved based on the CLASSIC study, itwas decided to close the study early. With a median follow-up duration of 56.9 months, the 3-year DFS rate between two groups was not significantly different (49.14% in DS group vs. 52.5% in SP group). The most common grade 3-4 adverse event was neutropenia (42.7% in DS and 38.5% in SP, p=0.351). SP group had more grade 3-4 anemia (1.3% vs. 11.5%, p=0.037), whereas grade 3-4 hand-foot syndrome (4.1% vs. 0%, p=0.025) and mucositis (10.7% vs. 2.6%, p=0.001) were more common in DS group. Fifty-one patients (68%) in DS group and 52 (66.7%) in SP group finished planned treatment. CONCLUSION: Our findings suggest that SP or DS is an effective and tolerable option for patients with curatively resected stage III gastric cancer.
