Sulfuretin Prevents Obesity and Metabolic Diseases in Diet Induced Obese Mice.
10.4062/biomolther.2018.090
- Author:
Suji KIM
1
;
No Joon SONG
;
Seo Hyuk CHANG
;
Gahee BAHN
;
Yuri CHOI
;
Dong Kwon RHEE
;
Ui Jeong YUN
;
Jinhee CHOI
;
Jeon LEE
;
Jae Hyuk YOO
;
Donghan SHIN
;
Ki Moon PARK
;
Hee KANG
;
Sukchan LEE
;
Jin Mo KU
;
Yoon Shin CHO
;
Kye Won PARK
Author Information
1. Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon 16419, Republic of Korea. kwpark@skku.edu
- Publication Type:Original Article
- Keywords:
Sulfuretin;
Obesity;
Adipocyte;
Metabolic diseases;
Diabetes;
Atf3
- MeSH:
Activating Transcription Factor 3;
Adipocytes;
Adiponectin;
Adipose Tissue, White;
Animals;
Diet*;
Insulin Resistance;
Metabolic Diseases*;
Mice;
Mice, Obese*;
Microarray Analysis;
Obesity*;
RNA, Messenger
- From:Biomolecules & Therapeutics
2019;27(1):107-116
- CountryRepublic of Korea
- Language:English
-
Abstract:
The global obesity epidemic and associated metabolic diseases require alternative biological targets for new therapeutic strategies. In this study, we show that a phytochemical sulfuretin suppressed adipocyte differentiation of preadipocytes and administration of sulfuretin to high fat diet-fed obese mice prevented obesity and increased insulin sensitivity. These effects were associated with a suppressed expression of inflammatory markers, induced expression of adiponectin, and increased levels of phosphorylated ERK and AKT. To elucidate the molecular mechanism of sulfuretin in adipocytes, we performed microarray analysis and identified activating transcription factor 3 (Atf3) as a sulfuretin-responsive gene. Sulfuretin elevated Atf3 mRNA and protein levels in white adipose tissue and adipocytes. Consistently, deficiency of Atf3 promoted lipid accumulation and the expression of adipocyte markers. Sulfuretin’s but not resveratrol’s anti-adipogenic effects were diminished in Atf3 deficient cells, indicating that Atf3 is an essential factor in the effects of sulfuretin. These results highlight the usefulness of sulfuretin as a new anti-obesity intervention for the prevention of obesity and its associated metabolic diseases.
