Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea.
- Author:
Jun Yong CHOI
1
;
Jin Ok OH
;
Jin Young AHN
;
Heun CHOI
;
Jung Ho KIM
;
Hye SEONG
;
Su Jin JEONG
;
Nam Su KU
;
Joon Sup YEOM
;
Jae Phil CHOI
Author Information
- Publication Type:Brief Communication
- Keywords: Middle East respiratory syndrome coronavirus; Neutralizing antibodies; Serum
- MeSH: Antibodies, Neutralizing; Antiviral Agents*; Coronavirus Infections; Humans; Korea*; Middle East Respiratory Syndrome Coronavirus; Pneumonia
- From:Clinical and Experimental Vaccine Research 2019;8(1):86-88
- CountryRepublic of Korea
- Language:English
- Abstract: We evaluated the neutralizing activity in serum from three patients >1 year after recovery from Middle East respiratory syndrome (MERS) associated with mild pneumonia treated with antivirals during the MERS outbreak in South Korea at 2015. The neutralizing activity in serum was measured by pseudovirus inhibition assays. Three-fold diluted serum of subjects showed only 9.7%, 10.3%, and 2.2% reductions in relative light units. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection.
