Leptospirosis as Unusual Trigger of Systemic Lupus Erythematosus.
- Author:
Jinhee LEE
1
;
Yang Ree KIM
;
Chong Hyeon YOON
Author Information
- Publication Type:Case Report
- Keywords: Systemic lupus erythematosus; Leptospirosis; Myocarditis
- MeSH: Adult; Antibodies; Diagnosis; Dyspnea; Edema; Exanthema; Female; Fever; Humans; Hypokinesia; L-Lactate Dehydrogenase; Leptospira; Leptospirosis*; Leukopenia; Lupus Erythematosus, Systemic*; Myalgia; Myocarditis; Thrombocytopenia
- From:Journal of Rheumatic Diseases 2019;26(1):79-82
- CountryRepublic of Korea
- Language:English
- Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder of an unknown origin. The role of leptospirosis as a triggering factor for SLE is unknown. This paper reports an uncommon case of SLE following a leptospira infection. A 29-year-old female was referred due to fevers, myalgia, and facial edema with rash. Laboratory investigations revealed a hepatic dysfunction, significantly raised lactate dehydrogenase with marked leukopenia and thrombocytopenia. A diagnosis of leptospirosis was confirmed. The patient was treated with antibiotic therapy for leptospirosis. She developed dyspnea after one week. The echocardiogram revealed global hypokinesia with a decreased ejection fraction. A positivity of antinuclear, anti-DNA, and anti-Smith antibodies, together with clinical and laboratory improvement by steroid therapy, led to the diagnosis of SLE. This case highlights the presence of concurrent SLE and leptospirosis. As the symptoms of SLE are similar to leptospirosis, accurate diagnosis through high suspicion is essential for appropriate treatment.
