A Case of Acute Panmyelosis with Myelofibrosis.
- Author:
Young Jin LEE
1
;
Moo Rim PARK
Author Information
1. Department of Laboratory Medicine, Wonkwang University, School of Medicine, Iksan, Korea. jin20@wmc.wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
Acute panmyelosis with myelofibrosis;
WHO classification;
AML;
Leukoerythrob-lastosis
- MeSH:
Blood Platelets;
Bone Marrow;
Cell Line;
Classification;
Dizziness;
Drug Therapy;
Dyspnea;
Follow-Up Studies;
Idarubicin;
Leukemia, Myeloid, Acute;
Pancytopenia;
Primary Myelofibrosis*
- From:The Korean Journal of Laboratory Medicine
2004;24(4):207-211
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We experienced a case of acute panmyelosis with myelofibrosis, one of the acute myeloblastic leukemia (AML) subtypes according to WHO classification. A 44 year old man presented with a laborious dyspnea, dizziness, and generalized weakness. On admission, the peripheral blood revealed pancytopenia (hemoglobin 4.0 g/dL, WBC 2, 300/microliter, platelet 92, 000/microliter) with leukoerythroblastosis. The bone marrow (BM) aspirate yielded inadequate material but histological sections showed hyper-cellularity, proliferation of trilineage cell lines (panmyelosis) with extensive myelofibrosis, and clusters of immature cells at paratrabecular area. On ultrasonographic examination, no evidence of hepato-splenomegaly or any other abnormalities were noted. The follow-up BM study after the chemotherapy with Ara C for 7 days and idarubicin for 3 days showed no significant changes in pancytopenia and myelofibrosis but revealed a significant decrease in BM cellularity and blasts. We review and report the literature on acute panmyelosis with myelofibrosis.
