Regulation of Neural Stem Cell Fate by Natural Products.
10.4062/biomolther.2018.184
- Author:
Hyun Jung KIM
1
Author Information
1. Laboratory of Molecular Stem Cell Pharmacology, College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea. hyunjungkim@cau.ac.kr
- Publication Type:Review
- Keywords:
Neural stem cells;
Cell fate;
Neurogenesis;
Differentiation;
Antioxidative;
Neuroprotection
- MeSH:
Biological Products*;
Embryonic Stem Cells;
Fetus;
Induced Pluripotent Stem Cells;
Nervous System;
Neural Stem Cells*;
Neurodegenerative Diseases;
Neurogenesis;
Neuroglia;
Neurons;
Neuroprotection;
Phytochemicals;
Regenerative Medicine
- From:Biomolecules & Therapeutics
2019;27(1):15-24
- CountryRepublic of Korea
- Language:English
-
Abstract:
Neural stem cells (NSCs) can proliferate and differentiate into multiple cell types that constitute the nervous system. NSCs can be derived from developing fetuses, embryonic stem cells, or induced pluripotent stem cells. NSCs provide a good platform to screen drugs for neurodegenerative diseases and also have potential applications in regenerative medicine. Natural products have long been used as compounds to develop new drugs. In this review, natural products that control NSC fate and induce their differentiation into neurons or glia are discussed. These phytochemicals enable promising advances to be made in the treatment of neurodegenerative diseases.
