White-Matter Hyperintensities and Lacunar Infarcts Are Associated with an Increased Risk of Alzheimer's Disease in the Elderly in China.
- Author:
Shuai YE
1
;
Shuyang DONG
;
Jun TAN
;
Le CHEN
;
Hai YANG
;
Yang CHEN
;
Zeyan PENG
;
Yingchao HUO
;
Juan LIU
;
Mingshan TANG
;
Yafei LI
;
Huadong ZHOU
;
Yong TAO
Author Information
- Publication Type:Original Article
- Keywords: Alzheimer's disease; small-vessel diseases; white-matter hyperintensities
- MeSH: Activities of Daily Living; Adult; Aged*; Alzheimer Disease*; China*; Cognition; Cohort Studies; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Strikes, Employee; Stroke, Lacunar*
- From:Journal of Clinical Neurology 2019;15(1):46-53
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND AND PURPOSE: This study investigated the contribution of white-matter hyperintensities (WMH) and lacunar infarcts (LI) to the risk of Alzheimer's disease (AD) in an elderly cohort in China. METHODS: Older adults who were initially cognitively normal were examined with MRI at baseline, and followed for 5 years. WMH were classified as mild, moderate, or severe, and LI were classified into a few LI (1 to 3) or many LI (≥4). Cognitive function was assessed using the Mini Mental State Examination and the Activities of Daily Living scale. RESULTS: Among the 2,626 subjects, 357 developed AD by the end of the 5-year follow-up period. After adjusting for age and other potential confounders, having only WMH, having only LI, and having both WMH and LI were associated with an increased risk of developing AD compared with having neither WMH nor LI. Moderate and severe WMH were associated with an increased risk of developing AD compared with no WMH. Furthermore, patients with many LI had an increased risk of developing AD compared with no LI. CONCLUSIONS: Having moderate or severe WMH and many LI were associated with an increased risk of developing AD, with this being particularly striking when both WMH and LI were present.
