Clinical genetics of defects in thyroid hormone synthesis.
10.6065/apem.2018.23.4.169
- Author:
Min Jung KWAK
1
Author Information
1. Department of Pediatrics, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea. glorymj0123@gmail.com
- Publication Type:Review
- Keywords:
Congenital hypothyroidism;
Dyshormonogenesis;
Genetics;
Whole exome sequencing
- MeSH:
Congenital Hypothyroidism;
Diagnosis;
Exome;
Genetics*;
Thyroid Gland*;
Wills
- From:Annals of Pediatric Endocrinology & Metabolism
2018;23(4):169-175
- CountryRepublic of Korea
- Language:English
-
Abstract:
Thyroid dyshormonogenesis is characterized by impairment in one of the several stages of thyroid hormone synthesis and accounts for 10%–15% of congenital hypothyroidism (CH). Seven genes are known to be associated with thyroid dyshormonogenesis: SLC5A5 (NIS), SCL26A4 (PDS), TG, TPO, DUOX2, DUOXA2, and IYD (DHEAL1). Depending on the underlying mechanism, CH can be permanent or transient. Inheritance is usually autosomal recessive, but there are also cases of autosomal dominant inheritance. In this review, we describe the molecular basis, clinical presentation, and genetic diagnosis of CH due to thyroid dyshormonogenesis, with an emphasis on the benefits of targeted exome sequencing as an updated diagnostic approach.
