Interpretation of androgen and anti-Mullerian hormone profiles in a Hispanic cohort of 5- to 8-year-old girls with premature adrenarche.
10.6065/apem.2018.23.4.210
- Author:
Preneet Cheema BRAR
1
;
Elena DINGLE
;
Daniela OVADIA
;
Sarah PIVO
;
Veeramac PRASAD
;
Raphael DAVID
Author Information
1. Division of Pediatric Endocrinology, Department of Pediatrics, New York University School of Medicine, New York, NY, USA. preneet.brar@nyumc.org
- Publication Type:Original Article
- Keywords:
Anti-mullerian hormone;
Adrenarche;
Polycystic ovary syndrome;
Androge
- MeSH:
17-alpha-Hydroxyprogesterone;
Adrenarche*;
Anti-Mullerian Hormone*;
Body Mass Index;
Child*;
Cohort Studies*;
Electronic Health Records;
Female*;
Hispanic Americans*;
Humans;
Polycystic Ovary Syndrome;
Reference Values;
Retrospective Studies;
Testosterone
- From:Annals of Pediatric Endocrinology & Metabolism
2018;23(4):210-214
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Premature adrenarche (PA) often leads to polycystic ovary syndrome (PCOS). Higher anti-mullerian hormone (AMH) levels are reported in PCOS. We studied the androgen profile and AMH profiles in Hispanic girls with PA (aged 5–8 years) and age and body mass index (BMI) matched controls. METHODS: Retrospective review of electronic medical records of girls who met the inclusion criteria for premature adrenarche were done. RESULTS: PA girls (n=76) were matched to control girls (n=12) for age (mean±standard deviation) (6.7±1 years vs. 6.2±1.3 years) and BMI (20±10 kg/m2 vs. 17.8±2.7 kg/m2). Dehydroepiandrostenedione sulfate (63.3±51.3 μg/dL vs. 29.8±17.3 μg/dL, P < 0.001) and testosterone levels (11.4±4.8 ng/dL vs. 8.2±2.9 ng/dL, P=0.001) were significantly higher in the PA group than controls. AMH values ( < 14 years: reference range, 0.49–3.15 ng/mL) were 3.2±2.2 ng/mL vs. 4.6± 3.2 ng/mL respectively in the PA and control groups and were not different (P=0.4). AMH did not show a correlation with bone age (P=0.1), and testosterone (P=0.9) in the PA group. 17-hydroxyprogesterone levels (17-OHP ng/dL) were 39.5±30.5 ng/dL vs. 36.8±19.8 ng/dL in PA versus control girls. The concentration of 17-OHP was not statistically different between the control and PA groups. CONCLUSIONS: Higher AMH was not observed in PA girls and no correlation with BA and androgen levels was observed.
