Differences in Psychopathology between Offspring of Parents with Bipolar I Disorder and Those with Bipolar II Disorder: A Cross-Sectional Study.
- Author:
Hyeon Ah LEE
1
;
Ji Sun KIM
;
Yeon Jung LEE
;
Nam Hun HEO
;
Se Hoon SHIM
;
Young Joon KWON
Author Information
- Publication Type:Original Article
- Keywords: Bipolar I disorder; Bipolar II disorder; Offspring; Schoolchildren; Adolescent
- MeSH: Adolescent; Cross-Sectional Studies*; Depression; Diagnosis; Humans; Mood Disorders; Parents*; Psychopathology*
- From:Psychiatry Investigation 2018;15(12):1135-1143
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: The aim of this study was to evaluate differences in psychopathology between offspring of parents with bipolar I disorder (BP-I) and those with bipolar II disorder (BP-II). METHODS: The sample included 201 offspring between 6 and 17 years of age who had at least one parent with BP-I or BP-II. The offspring were diagnostically evaluated using the Korean Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. Psychopathology and Clinical characteristics were evaluated, including lifetime DSM-5 diagnoses, depression, and childhood trauma. Lifetime DSM-5 diagnoses were also compared between schoolchildren aged 6 to 11 years and adolescents aged 12 to 17 years. RESULTS: In lifetime DSM-5 diagnoses, offspring of parents with BP-I had significantly increased risk of developing MDD and BP-I than those with BP-II. Regarding clinical characteristics, ADHD rating scale and childhood trauma scale were significantly higher in offspring of parents with BP-I than that in those with BP-II. CONCLUSION: The present study supports that BP-I may be etiologically distinct from BP-II by a possible genetic liability. Our findings indicate that additional research related to bipolar offspring is needed to enhance understanding of differences between BP-I and BP-II.
