Gray Matter Volume Reductions Were Associated with TPH1 Polymorphisms in Depressive Disorder Patients with Suicidal Attempts.
- Author:
Sang Min LEE
1
;
Soyoen LEE
;
Won Sub KANG
;
Geon Ho JAHNG
;
Hae Jeong PARK
;
Su Kang KIM
;
Jin Kyung PARK
Author Information
- Publication Type:Original Article
- Keywords: Depressive disorder; Suicidal attempt; Gray matter volume; TPH1 gene
- MeSH: Alleles; Brain; Depressive Disorder*; Frontal Lobe; Genotype; Gray Matter*; Gyrus Cinguli; Humans; Palatine Tonsil; Prefrontal Cortex; Somatosensory Cortex; Temporal Lobe
- From:Psychiatry Investigation 2018;15(12):1174-1180
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: Structural changes of brain areas have been reported in depressive disorder and suicidal behavior (SB), in which TPH1 also has been known as a promising candidate gene. We investigated gray matter volume (GMV) differences, TPH1 rs1800532 and rs1799913 polymorphisms previously found to be associated with depressive disorder and SB, and the relationship between the two markers. METHODS: Thirteen depressive disorder patients with suicidal attempts (SA) and twenty healthy controls were included. We examined GMV differences using a voxel-based morphometry and regions of interest analysis. Direct sequencing was used for genotyping. RESULTS: The patients showed significant GMV reduction in left cerebral region including middle frontal gyrus, inferior frontal gyrus, and anterior cingulate cortex; in right middle temporal gyrus; in left cerebellar tonsil; and in right cerebral region including precentral gyrus and postcentral gyrus (corrected p < 0.005). The right precentral and postcentral gyri GMV values of AA and CA genotypes patients were significantly decreased compared to those of CC genotype subjects (corrected p=0.040). CONCLUSION: These findings show the possibility that both GMV reductions and TPH1 rs1800532/rs1799913 A allele may be involved in the pathogenesis of depressive disorder patients with SA.
