Gastric Adenocarcinoma of Fundic Gland Type with Aggressive Transformation and Lymph Node Metastasis: a Case Report.
- Author:
Yasuhiro OKUMURA
1
;
Manabu TAKAMATSU
;
Manabu OHASHI
;
Yorimasa YAMAMOTO
;
Noriko YAMAMOTO
;
Hiroshi KAWACHI
;
Satoshi IDA
;
Koshi KUMAGAI
;
Souya NUNOBE
;
Naoki HIKI
;
Takeshi SANO
Author Information
- Publication Type:Case Report
- Keywords: Gastric gland; Lymph nodes; Neoplasm metastasis
- MeSH: Adenocarcinoma*; Biopsy; Endoscopy; Endosonography; Gastrectomy; Gastric Mucosa; Humans; Lymph Node Excision; Lymph Nodes*; Middle Aged; Mucous Membrane; Neoplasm Metastasis*
- From:Journal of Gastric Cancer 2018;18(4):409-416
- CountryRepublic of Korea
- Language:English
- Abstract: A 55-year-old man visited our hospital for a detailed examination of a gastric submucosal tumor that was first detected 10 years prior. The tumor continued to grow and had developed a depressed area in its center. A histopathological examination of biopsy specimens revealed gastric adenocarcinoma of the fundic gland type (GA-FG). It was diagnosed as T2 based on the invasion depth as determined by white-light endoscopy and endoscopic ultrasonography. A total gastrectomy with lymphadenectomy was performed and a GA-FG in the mucosa and submucosa was confirmed histopathologically. However, there was a gradual transition to an infiltrative tubular adenocarcinoma with poorly differentiated components in the muscular and subserosal layers. Metastasis was identified in a dissected lymph node (LN). This is the first report of a GA-FG progressing to an aggressive cancer with LN metastasis. These findings modify our understanding of the pathophysiology of GA-FG.
