Neutrophil-to-lymphocyte Ratio as A Predictor of Aspiration Pneumonia in Drug Intoxication Patients.
- Author:
Jeong Beom LEE
1
;
Sun Hwa LEE
;
Seong Jong YUN
;
Seokyong RYU
;
Seung Woon CHOI
;
Hye Jin KIM
;
Tae Kyung KANG
;
Sung Chan OH
;
Suk Jin CHO
;
Beom Sok SEO
Author Information
- Publication Type:Original Article
- Keywords: Aspiration pneumonia; Neutrophil-lymphocyte ratio; Drug intoxication; Predictive factor; Emergency medicine
- MeSH: Emergencies; Emergency Medicine; Emergency Service, Hospital; Humans; Logistic Models; Lymphocyte Count; Neutrophils; Pneumonia, Aspiration*; Prognosis; ROC Curve; Sensitivity and Specificity
- From:Journal of The Korean Society of Clinical Toxicology 2018;16(2):61-67
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: To evaluate the association between neutrophil-to-lymphocyte ratio (NLR) and occurrence of aspiration pneumonia in drug intoxication (DI) patients in the emergency department (ED) and to evaluate the relationship between NLR and length of hospital admission/intensive care unit (ICU) admission. METHODS: A total of 466 patients diagnosed with DI in the ED from January 2016 to December 2017 were included in the analysis. The clinical and laboratory results, including NLR, were evaluated as variables. NLR was calculated as the absolute neutrophil count/absolute lymphocyte count. To evaluate the prognosis of DI, data on the development of aspiration pneumonia were obtained. Also, we evaluated the relationship between NLR and length of hospital admission and between NLR and length of ICU admission. Statistically, multivariate logistic regression analyses, receiver-operating characteristic (ROC) curve analysis, and Pearson's correlation (ρ) were performed. RESULTS: Among the 466 DI patients, 86 (18.5%) developed aspiration pneumonia. Multivariate logistic regression analysis revealed NLR as an independent factor in predicting aspiration pneumonia (odds ratio, 1.7; p=0.001). NLR showed excellent predictive performance for aspiration pneumonia (areas under the ROC curves, 0.815; cut-off value, 3.47; p < 0.001) with a sensitivity of 86.0% and a specificity of 72.6%. No correlations between NLR and length of hospital admission (ρ=0.195) and between NLR and length of ICU admission (ρ=0.092) were observed. CONCLUSION: The NLR is a simple and effective marker for predicting the occurrence of aspiration pneumonia in DI patients. Emergency physicians should be alert for aspiration pneumonia in DI patients with high NLR value (>3.47).
