The Model for Evaluation on Blood Flow of Functional Food in Human Intervention Study.
- Author:
Yeni LIM
1
;
Oran KWON
;
Ji Yeon KIM
Author Information
- Publication Type:Clinical Trial ; Review
- Keywords: Atherosclerosis; Blood circulation; Blood vessels; Platelets; Dyslipidemias
- MeSH: Atherosclerosis; Biological Products; Blood Circulation; Blood Vessels; Dyslipidemias; Functional Food*; Healthy Volunteers; Humans*; Hyperlipidemias; Obesity; Platelet Activation; Platelet Aggregation; Prevalence; Smoking
- From:Journal of Lipid and Atherosclerosis 2018;7(2):88-97
- CountryRepublic of Korea
- Language:Korean
- Abstract: The prevalence of atherothrombotic disease continues to rise, presenting an increasing number of challenges to modern society and creating interest in functional foods. Platelet activation, adhesion, and aggregation at vascular endothelial disruption sites are key events in atherothrombotic disease. Physiological challenges such as hyperlipidemia, obesity, and cigarette smoking are associated with vascular changes underlying platelet aggregation and inflammatory processes. However, it is difficult to determine the beneficial response of functional foods in healthy subjects. To address this problem, challenge models and high-risk models related to smokers, obesity, and dyslipidemia are proposed as sensitive measures to evaluate the effects of functional foods in healthy subjects. In this review, we construct a model to evaluate the effects of functional food such as natural products on blood flow based on a human intervention study.
