L-plastin: Structure, Regulation, and Roles in Cancer Invasion and in Macrophages.
10.4167/jbv.2018.48.4.175
- Author:
Hwa Jung KIM
1
;
Hwang Ho LEE
Author Information
1. Department of Microbiology, College of Medicine, Chungnam National University, Daejeon, Korea.
- Publication Type:Review
- Keywords:
L-plastin;
Calcium;
Phosphorylation
- MeSH:
Actin Cytoskeleton;
Calcium;
Cytoskeleton;
Intermediate Filaments;
Lymphocytes;
Macrophages*;
Microfilament Proteins;
Microtubules;
Monocytes;
Phosphorylation
- From:Journal of Bacteriology and Virology
2018;48(4):175-180
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The cytoskeleton consists of 3 filamentous components: intermediate filaments, microtubules, and actin filaments. Actin filaments continuously assemble and disassemble far out of equilibrium to adapt cells in response to external stimuli. Actin filaments organization and dynamic are controlled by a multitude of actin-binding proteins including actin-bundling proteins. L-plastin, expressed abundantly in lymphocytes and monocytes, is an actin-bundling protein that roles in immune defense and in metastatic invasion of cancer cells. The actin-bundling activity of L-plastin is regulated not only by intracellular calcium concentration, but by phosphorylation of Ser5. The actin-bundling activity of L-pastin decreases by increased calcium concentration but is promoted by phosphorylation of Ser5. The morphology changes and motility of cells requires continuous remodeling of actin filaments which demands the sensitive nature of L-plastin to Ca2+-signal, phosphorylation of Ser5, and probably additional regulation. This review briefly describes the structure and regulation of L-plastin, and roles for L-plastin in cancer invasion and in macrophages.
