The Effect of Dorzolamide-Timolol and Latanoprost on Redox Cycle in Aqueous Humor of Rabbit.
10.3341/jkos.2009.50.3.424
- Author:
Sang Woo PARK
1
;
Seung Hyun LEE
;
Gui Hyeong MUN
Author Information
1. Department of Ophthalmology, Chonnam National University Medical School & Hospital, Gwangju, Korea. exo70@naver.com
- Publication Type:Original Article
- Keywords:
Ascorbic acid;
Dorzolamide-timolol;
Latanoprost;
Superoxide dismutase
- MeSH:
Aqueous Humor;
Ascorbic Acid;
Eye;
Oxidation-Reduction;
Prostaglandins F, Synthetic;
Superoxide Dismutase
- From:Journal of the Korean Ophthalmological Society
2009;50(3):424-428
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the effect of dorzolamide-timolol and latanoprost on redox cycle of superoxide dismutase (SOD) and ascorbic acid in the aqueous humor of the rabbit. METHODS: Group 1 (20 eyes of 10 rabbits) was instilled with dorzolamide-timolol in the right eye and Group 2 (20 eyes of 10 rabbits) was instilled with latanoprost in the same manner. Four weeks after instillation, SOD activity and ascorbic acid concentration were analyzed. RESULTS: In Group 1, SOD activity and ascorbic acid concentration of the right eye and left eye were 15.7% and 19.3% (p=0.27), 2.7 pM and 2.6 pM (p=0.47), respectively. In Group 2, SOD activity and ascorbic acid concentration of the right and left eye were 22.3% and 27.6% (p=0.14), 2.3 pM and 2.1 pM (p=0.89), respectively. CONCLUSIONS: There was no significant difference of SOD activity and ascorbic acid concentration between both eyes in Group 1 and 2.
