Does Serum Osmolarity Change as a Result of the Reflex Neuroprotective Mechanism of Cerebral Osmo-Regulation after Minor Head Trauma?.
10.3340/jkns.2009.45.3.151
- Author:
Naci BALAK
1
;
Nilgun ISIKSACAN
;
Recai TURKOGLU
Author Information
1. Department of Neurosurgery, Bakirkoy Sadi Konuk Education and Research Hospital, Istanbul, Turkey. naci.balak@attglobal.net
- Publication Type:Original Article
- Keywords:
Biomarkers;
Brain injury;
Head trauma;
Neurophysiology;
Osmolarity
- MeSH:
Aged;
Biomarkers;
Brain;
Brain Injuries;
Central Nervous System;
Craniocerebral Trauma;
Extremities;
Head;
Hemodynamics;
Humans;
Neurophysiology;
Osmolar Concentration;
Reflex
- From:Journal of Korean Neurosurgical Society
2009;45(3):151-156
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: It is well known that changes in cerebral hemodynamics occur after traumatic brain injury (TBI). Osmo-regulation in the brain is important for maintaining a constant milieu in the central nervous system. Nevertheless, to our knowledge, early osmolarity changes after minor head injury have not been studied until now. METHODS: In this study, serum osmolarity was measured in 99 patients with minor head trauma. As a control group, blood samples were drawn from 99 patients who had a minor trauma in an extremity. Serum osmolarity was estimated using a fully automatic biochemical autoanalyzer within the first 3 hours after the trauma. RESULTS: The mean serum osmolarity levels were 286.08+/-10.17 mOsm/L in the study group and 290.94+/-5.65 mOsm/L in the control group (p<0.001). However, after age adjustment between the study and control groups, this statistical significance was found to be valid only for patients over 30 years of age. CONCLUSION: It was noted that serum osmolarity levels decrease in the first 3 hours following minor head trauma in patients over 30 years of age. Further studies into this area could provide guidance for the management/treatment of elderly patients.
