Association between the simultaneous decrease in the levels of soluble vascular cell adhesion molecule-1 and S100 protein and good neurological outcomes in cardiac arrest survivors.
- Author:
Min Jung KIM
1
;
Taegyun KIM
;
Gil Joon SUH
;
Woon Yong KWON
;
Kyung Su KIM
;
Yoon Sun JUNG
;
Jung In KO
;
So Mi SHIN
;
A Reum LEE
Author Information
- Publication Type:Original Article
- Keywords: Cardiac arrest; Cardiopulmonary resuscitation; Blood-brain barrier; Endothelium
- MeSH: Blood-Brain Barrier; Cardiopulmonary Resuscitation; Cell Adhesion; Cell Adhesion Molecules; E-Selectin; Emergencies; Endothelium; Heart Arrest*; Humans; Intensive Care Units; Intercellular Adhesion Molecule-1; Observational Study; Out-of-Hospital Cardiac Arrest; Prospective Studies; Retrospective Studies; S100 Proteins; Survivors*; Vascular Cell Adhesion Molecule-1*
- From: Clinical and Experimental Emergency Medicine 2018;5(4):211-218
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: This study aimed to determine whether simultaneous decreases in the serum levels of cell adhesion molecules (intracellular cell adhesion molecule-1 [ICAM-1], vascular cell adhesion molecule-1 [VCAM-1], and E-selectin) and S100 proteins within the first 24 hours after the return of spontaneous circulation were associated with good neurological outcomes in cardiac arrest survivors. METHODS: This retrospective observational study was based on prospectively collected data from a single emergency intensive care unit (ICU). Twenty-nine out-of-hospital cardiac arrest survivors who were admitted to the ICU for post-resuscitation care were enrolled. Blood samples were collected at 0 and 24 hours after ICU admission. According to the 6-month cerebral performance category (CPC) scale, the patients were divided into good (CPC 1 and 2, n=12) and poor (CPC 3 to 5, n=17) outcome groups. RESULTS: No difference was observed between the two groups in terms of the serum levels of ICAM-1, VCAM-1, E-selectin, and S100 at 0 and 24 hours. A simultaneous decrease in the serum levels of VCAM-1 and S100 as well as E-selectin and S100 was associated with good neurological outcomes. When other variables were adjusted, a simultaneous decrease in the serum levels of VCAM-1 and S100 was independently associated with good neurological outcomes (odds ratio, 9.285; 95% confidence interval, 1.073 to 80.318; P=0.043). CONCLUSION: A simultaneous decrease in the serum levels of soluble VCAM-1 and S100 within the first 24 hours after the return of spontaneous circulation was associated with a good neurological outcome in out-of-hospital cardiac arrest survivors.
