Obesity-Induced Peritoneal Dissemination of Ovarian Cancer and Dominant Recruitment of Macrophages in Ascites.
- Author:
Rosa Mistica C IGNACIO
1
;
Eun Sook LEE
;
Andrew J WILSON
;
Alicia BEEGHLY-FADIEL
;
Margaret M WHALEN
;
Deok Soo SON
Author Information
- Publication Type:Brief Communication
- Keywords: Obesity; Macrophages; Chemokines; Ascites; Ovarian cancer
- MeSH: Adipocytes; Animals; Ascites*; Chemokine CXCL1; Chemokines; Glucose; Granulocyte Colony-Stimulating Factor; Macrophage Colony-Stimulating Factor; Macrophages*; Mice; Mice, Obese; Neoplasm Metastasis; Obesity; Ovarian Neoplasms*; Peritoneal Cavity
- From:Immune Network 2018;18(6):e47-
- CountryRepublic of Korea
- Language:English
- Abstract: One-fifth of cancer deaths are associated with obesity. Because the molecular mechanisms by which obesity affects the progression of ovarian cancer (OC) are poorly understood, we investigated if obesity could promote the progression of OC cells using the postmenopausal ob/ob mouse model and peritoneal dissemination of mouse ID8 OC cells. Compared to lean mice, obese mice had earlier OC occurrence, greater metastasis throughout the peritoneal cavity, a trend toward shorter survival, and higher circulating glucose and proinflammatory chemokine CXCL1 levels. Ascites in obese mice had higher levels of macrophages (Mφ) and chemokines including CCL2, CXCL12, CXCL13, G-CSF and M-CSF. Omental tumor tissues in obese mice had more adipocytes than lean mice. Our data suggest that obesity may accelerate the peritoneal dissemination of OC through higher production of pro-inflammatory chemokines and Mφ recruitment.
