Gastric Cancer Stem Cells: Mechanisms and Therapeutic Approaches.
10.3349/ymj.2018.59.10.1150
- Author:
Yan FU
1
;
Peizhun DU
;
Jing ZHAO
;
Cheng'en HU
;
Yunyun QIN
;
Guangjian HUANG
Author Information
1. Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China. huangguangjian12@126.com
- Publication Type:Review
- Keywords:
Cancer stem cells;
gastric cancer;
identification and isolation;
molecular mechanism;
targeted therapy
- MeSH:
Biomarkers;
Drug Resistance;
Hope;
Humans;
Neoplasm Metastasis;
Neoplastic Stem Cells;
Recurrence;
Stem Cells*;
Stomach Neoplasms*
- From:Yonsei Medical Journal
2018;59(10):1150-1158
- CountryRepublic of Korea
- Language:English
-
Abstract:
Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. GC stem-like cells (GCSCs), with unlimited self-renewal, differentiation, and tumor-regenerating capacities, contribute significantly to the refractory features of GC and have gained increasing attention for their role in GC drug resistance, relapse, and metastasis. Therapies targeting GCSCs seem to be one of the most promising methods to improve the outcomes of GC patients. Extensive investigations have attempted to outline the regulatory mechanisms in GCSCs and to develop GCSCs-targeting therapies with which to diminish GC drug resistance, metastasis and relapse. To the best of our knowledge, there is a lack of reviews summarizing these studies. In this review, we systematically recapitulated findings regarding the regulatory mechanisms of GCSCs, as well as therapies that target GCSCs, hoping to support the development of prognostic biomarkers and GCSCs-targeting anticancer therapies in GC.
