Detection of bone marrow involvement with FDG PET/CT in patients with newly diagnosed lymphoma.
- Author:
H Tahsin ÖZPOLAT
1
;
Ebru YILMAZ
;
Hasan Sami GOKSOY
;
Sahre ÖZPOLAT
;
Oner DOGAN
;
Seher Nilgun UNAL
;
Meliha NALCACI
Author Information
- Publication Type:Original Article
- Keywords: Lymphoma; Bone marrow biopsy; PET/CT; Bone marrow involvement; Diffuse; Focal involvement
- MeSH: Biopsy; Blood Platelets; Bone Marrow*; Electrons; Hodgkin Disease; Humans; Leukocyte Count; Lymphoma*; Positron-Emission Tomography and Computed Tomography*
- From:Blood Research 2018;53(4):281-287
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Bone marrow involvement (BMI) affects the lymphoma stage, survival, and treatment. Bone marrow biopsy (BMB) and fluorodeoxyglucose (FDG) positron emission tomography- computed tomography (PET/CT) are useful techniques to detect BMI. Both have advantages and disadvantages. We aimed to identify factors that could be used to predict BMI with positive and negative results on PET/CT compare them with BMB in newly diagnosed patients with lymphoma. METHODS: We included 22 non-Hodgkin and 16 Hodgkin lymphoma patients in this single center study. All patients had PET/CT examination and BMB before treatment. BMI in BMB was reported as negative or positive. Bone marrow was classified into 3 types by FDG uptake on PT/CT; diffuse involvement, focal involvement, and normal bone marrow. RESULTS: PET/CT and BMB results were concordant (7 positive, 15 negative) in 22 patients (57%). We evaluated concordant and discordant patient characteristics and risk-stratified patients for BMI. Our findings suggest that patients with diffuse FDG uptake on PET/CT, especially patients with advanced age and low platelet and white blood cell counts, are likely to have BMI and could potentially forego BMB. Patients with negative PET/CT findings and no significant laboratory abnormalities are very unlikely to have BMI. CONCLUSION: Our results suggest that BMI should not be decided solely based PET/CT or BMB findings. It is reasonable to use both diagnostic assays along with clinical and laboratory findings. PET/CT result, clinical and laboratory findings could be useful for predicting BMI in patient for whom BMB is contraindicated.
