Relationship between liver iron concentration determined by R2-MRI, serum ferritin, and liver enzymes in patients with thalassemia intermedia.
- Author:
Hayder AL-MOMEN
1
;
Shaymaa Kadhim JASIM
;
Qays Ahmed HASSAN
;
Hayder Hussein ALI
Author Information
- Publication Type:Original Article
- Keywords: Thalassemia intermedia; Iron overload; Serum ferritin; R2-MRI
- MeSH: Adolescent; Alanine Transaminase; beta-Thalassemia*; Chelation Therapy; Cross-Sectional Studies; Diagnosis; Ferritins*; Humans; Iron Overload; Iron*; Liver*; Magnetic Resonance Imaging; Puberty; Risk Factors; Splenectomy; Thalassemia*
- From:Blood Research 2018;53(4):314-319
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Iron overload is a risk factor affecting all patients with thalassemia intermedia (TI). We aimed to determine whether there is a relationship of serum ferritin (SF) and alanine aminotransferase (ALT) with liver iron concentration (LIC) determined by R2 magnetic resonance imaging (R2-MRI), to estimate the most relevant degree of iron overload and best time to chelate in patients with TI. METHODS: In this cross-sectional study, 119 patients with TI (mean age years) were randomly selected and compared with 120 patients who had a diagnosis of thalassemia major (TM). Correlations of LIC, as determined by R2-MRI, with SF and ALT levels, were assessed in all participants. A P-value < 0.05 was considered statistically significant. RESULTS: SF and LIC levels were lower in patients with TI than in those with TM; only ferritin values were significant. We found a statistically significant relationship between SF and LIC, with cut-off estimates of SF in patients with TI who had splenectomy and those who entered puberty spontaneously (916 and 940 ng/mL, respectively) with LIC >5 mg Fe/g dry weight (P < 0.0001). A significant relationship was also found for patients with TI who had elevated ALT level (63.5 U/L), of 3.15 times the upper normal laboratory limit, using a cut-off for LIC ≥5 mg Fe/g dry weight. CONCLUSION: We determined the cut-off values for ALT and SF indicating the best time to start iron chelation therapy in patients with TI, and found significant correlations among iron overload, SF, and ALT.
