Concurrent Use of Nefopam vs. Ketorolac with Opioid Analgesic for Post-operative Pain Management.
10.24304/kjcp.2018.28.4.279
- Author:
Yoon Hee KIM
1
;
Young Won KIM
;
Kyung Suk CHOI
;
Jung Hwa LEE
;
Eunsook LEE
;
Seungyeon KIM
;
YoungRok CHOI
;
Euni LEE
Author Information
1. Department of Pharmacy, Seoul National University Bundang Hospital, Gyeonggi-do 13620, Republic of Korea.
- Publication Type:Original Article
- Keywords:
Nefopam;
ketorolac;
postoperative pain management;
analgesic effects;
drug safety;
adverse events;
opioid analgesics
- MeSH:
Analgesia, Patient-Controlled;
Analgesics, Opioid;
Drug-Related Side Effects and Adverse Reactions;
Electronic Health Records;
Fentanyl;
Hand;
Hospitals, Teaching;
Humans;
Ketorolac*;
Korea;
Nefopam*;
Pain Management*;
Pain, Postoperative;
Paresthesia;
Passive Cutaneous Anaphylaxis;
Prescriptions;
Product Labeling;
Retrospective Studies
- From:Korean Journal of Clinical Pharmacy
2018;28(4):279-284
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To compare the analgesic effects and adverse drug reactions (ADRs) of fentanyl intravenous patient-controlled analgesia (ivPCA) with nefopam, a centrally acting analgesic agent with demonstrated opioid sparing activity, as compared to ketorolac in a tertiary teaching hospital. METHODS: A retrospective evaluation of electronic medical records was conducted on patient records including either nefopam or ketorolac with opioid ivPCA for post-operative pain management in general surgery department from January to December 2014. The status of pain control and ADRs were collected. RESULTS: Out of 6,330 general surgery cases, nefopam was given in 153 prescriptions (6.9%) and ketorolac in 81 prescriptions (3.6%). The level of pain control was not different between two groups (70.9% vs. 75.3%; p = 0.51), but ADRs were more frequently reported in nefopam group (9.8% vs. 2.5%; p < 0.05). New ADRs of hot flushes (n = 1) and paresthesia in hands (n = 1) were reported in nefopam group and they were unlisted in the approved package insert. No serious ADRs were reported in both groups. CONCLUSION: Our findings presented that nefopam showed a similar analgesic effect and higher ADR rates compared to ketorolac as an adjuvant to fentanyl iv PCA for postoperative pain management in general surgery patients in South Korea.
