BDNF Methylation and Suicidal Ideation in Patients with Acute Coronary Syndrome.
- Author:
Hee Ju KANG
1
;
Kyung Yeol BAE
;
Sung Wan KIM
;
Il Seon SHIN
;
Young Joon HONG
;
Youngkeun AHN
;
Myung Ho JEONG
;
Jin Sang YOON
;
Jae Min KIM
Author Information
- Publication Type:Brief Communication
- Keywords: Acute coronary syndrome; Suicidal ideation; Brain-derived neurotrophic factor methylation; Longitudinal study
- MeSH: Acute Coronary Syndrome*; Brain-Derived Neurotrophic Factor*; Depression; Epigenomics; Humans; Longitudinal Studies; Methylation*; Suicidal Ideation*; Suicide
- From:Psychiatry Investigation 2018;15(11):1094-1097
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: Patients with acute coronary syndrome (ACS) are at an increased risk of suicide. It is well known that epigenetic mechanisms may explain the pathophysiology of suicidal behavior including suicidal ideation (SI), but no study has explored these mechanisms in ACS populations. METHODS: In total, 969 patients were initially recruited within 2 weeks of the acute coronary event and, 711 patients were successfully followed up 1 year after ACS. SI was evaluated using the relevant items on the Montgomery-Åsberg Depression Rating Scale and covariates potentially affecting SI were estimated. RESULTS: Brain-derived neurotrophic factor (BDNF) hypermethylation was associated with SI in both the acute and chronic phases of ACS, although the association was not statistically significant in the acute phase after applying Bonferroni’s correction. CONCLUSION: These results suggested that BDNF hypermethylation may have played a role in an epigenetic predisposition for SI in ACS patients, particularly during the chronic phase.
